The widespread adoption of frontier agricultural technologies (aquaponics, hydroponics, insect farming) in the Mediterranean is constrained by inconsistent readiness levels and a lack of integrated Water-Energy-Food-Ecosystem (WEFE) Nexus policies. Key challenges include high startup costs, regulatory hurdles, and insufficient integration of renewable energy in agricultural innovation. FrontAg Nexus research highlights that accelerating frontier agriculture adoption necessitates targeted policy interventions and a strategic approach to enhancing readiness levels. Coherent policy frameworks, specific incentives, and robust R&D support are crucial to bridge the gap between technical feasibility, business readiness, social readiness (TRL, BRL, SRL), and practical implementation.