The interdependence of water, energy, food, and ecosystems (WEFE Nexus) is severely challenged by water scarcity in the Mediterranean, necessitating innovative agricultural solutions. Traditional farming and aquaculture methods often lead to high water consumption and nutrient waste, underscoring the urgent need for integrated, resource-efficient food production systems to ensure regional sustainability. The FrontAg Nexus project promotes integrated aquaponics and Recirculating Aquaculture Systems (RAS) as a circular food production solution. These closed-loop systems efficiently combine fish farming with soilless plant cultivation, leveraging nutrient-rich aquaculture water to fertilize crops. This innovative approach optimizes resource use by minimizing water discharge and recycling nutrients, embodying a waste-to-resource philosophy.